High prevalence of penicillin resistance and comparative in vitro activity of various antibiotics in clinical isolates of streptococcus pneumoniae isolated in the Province of Hainaut during winter 2004

A total of 154 isolates of Streptococcus pneumoniae obtained from 8 different centres in the province of Hainaut were included in this study. The susceptibilities to penicillin, amoxicillin, cefuroxime, ciprofloxacin, moxifloxacin, erythromycin and tetracycline were determined by a microdilution tec...

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Published inActa clinica belgica (English ed. Online) Vol. 60; no. 6; p. 345
Main Authors Vanhoof, R, Brouillard, J, Damée, S, d'Hondt, N, Haccourt, A, Mansoor, I, Marchal, J F, Philippart, I, Trigaux, F, Van Bosterhaut, B, Rossi, C, Van Bossuyt, E
Format Journal Article
LanguageEnglish
Published England 01.11.2005
Subjects
Adolescent
Adult
Belgium
Child
Child, Preschool
Drug Resistance, Bacterial
Humans
Microbial Sensitivity Tests
Middle Aged
Penicillin Resistance
Pilot Projects
Prevalence
Streptococcus pneumoniae
Belgium
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Summary:A total of 154 isolates of Streptococcus pneumoniae obtained from 8 different centres in the province of Hainaut were included in this study. The susceptibilities to penicillin, amoxicillin, cefuroxime, ciprofloxacin, moxifloxacin, erythromycin and tetracycline were determined by a microdilution technique following NCCLS recommendations. Decreased susceptibility to penicillin was 32.5% (23.4% intermediate and 9.1% high-level). The other insusceptibility rates were as follows: amoxicillin 1.9% [0% Resistance (R)], cefuroxime 23.4% (R 22.1%), ciprofloxacin 9.1% (R 1.3%), erythromycin 39.6% (R 38.3%), and tetracycline 31.8% (R 30.5%). No decreased susceptibility was found for moxifloxacin. MICs of amoxicillin, cefuroxime, erythromycin and tetracycline rose with those of penicillin for penicillin-insusceptible isolates. Most penicillin-insusceptible isolates remained fully susceptible to amoxicillin (94%), while moxifloxacin and ciprofloxacin kept an activity on 100% and 92% of these isolates respectively. Phenotypes with triple or quadruple insusceptibility were present in 31.2% of the isolates. Penicillin-insusceptible isolates showed a co-insusceptibility of 36.7% to erythromycin, 30.0% to tetracycline and 3.3% to ciprofloxacin.
ISSN:1784-3286
DOI:10.1179/acb.2005.052