Late Neutrophil Priming Following a Single Session of High-intensity Interval Exercise

• Published in: International journal of sports medicine Vol. 40; no. 3; p. 171
• Main Authors: de Oliveira Ottone, Vinícius, Costa, Karine Beatriz, Tossige-Gomes, Rosalina, de Matos, Mariana Aguiar, Brito-Melo, Gustavo, Magalhaes, Flavio de Castro, Esteves, Elizabethe Adriana, Amorim, Fabiano, Rocha-Vieira, Etel
• Format: Journal Article
• Language: English
• Published: Germany 01.03.2019
• Subjects: Adult; Cytokines - blood; High-Intensity Interval Training; Humans; Interleukin-8 - blood; L-Lactate Dehydrogenase - blood; Male; Muscle, Skeletal - metabolism; Neutrophils - metabolism; Oxidation-Reduction; Phagocytosis; Reactive Oxygen Species - metabolism; Young Adult
• ISSN: 1439-3964
• DOI: 10.1055/a-0810-8533

This study evaluated the effect of an acute high-intensity interval exercise (HIIE) session on the function of human neutrophils. Twelve sedentary men performed a HIIE session (8 bouts of 60 s at 90% of peak power, intercalated with 75 s of active recovery at 30 W). Neutrophils were collected before, 30 min and 24 h after the exercise session for the evaluation of phagocytic capacity, expression of phagocytic receptors, reactive oxygen species generation, and redox status. 24 h after the HIIE session, an increase was observed in both neutrophil phagocytic capacity and yeast-induced generation of reactive oxygen species, which indicates neutrophil priming in response to an acute HIIE session. Neutrophils also presented an increase in superoxide dismutase activity 24 h after the exercise. Improvement in neutrophil function was accompanied by increased serum levels of IL-8 and increased concentration of plasma lactate dehydrogenase. Our findings show a late activating effect of one HIIE session on neutrophils. We propose that priming of neutrophils by HIIE may play a role in skeletal muscle inflammation after exercise.