Asymmetric direct alpha,beta-functionalization of allenes via asymmetric carbopalladation

Asymmetric direct a,p-functionalization of allenes with chiral phosphine ligands was successfully achieved with extremely high enantioselectivity via asymmetric carbopalladation to the racemic allenes. The same palladium-catalyzed alkylation of a chiral allene was executed with complete enantiospeci...

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Bibliographic Details
Published inChemistry letters no. 5; pp. 397 - 398
Main Authors Hiroi, K, Kato, F, Yamagata, A
Format Journal Article
LanguageEnglish
Published TOKYO Chemical Soc Japan 01.05.1998
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
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Summary:Asymmetric direct a,p-functionalization of allenes with chiral phosphine ligands was successfully achieved with extremely high enantioselectivity via asymmetric carbopalladation to the racemic allenes. The same palladium-catalyzed alkylation of a chiral allene was executed with complete enantiospecificity. The stereochemistry of this reaction was determined and the mechanism of this asymmetric induction is proposed.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.1998.397