Risk of Neurological Decline in Patients With Temporal Lobe Brain Masses

• Published in: Anticancer research Vol. 43; no. 2; pp. 663 - 668
• Main Authors: Sweeney, Jared, Bondoc, Melanie, Bandlamuri, Sruti, Holdaway, Matt, Entezami, Pouya, O'Brien, Michael W, Adamo, Matthew A
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.02.2023
• Subjects: Adult; Brain Diseases; Confidence intervals; Humans; Patients; Regression analysis; Retrospective Studies; Risk; Statistical analysis; Temporal lobe; Temporal Lobe - diagnostic imaging; Brain tumor; neuro-oncological; resection; herniation; temporal
• ISSN: 0250-7005; 1791-7530
• DOI: 10.21873/anticanres.16203

The objective of this study was to assess which clinical and radiographic findings may be associated with neurological decline in patients with temporal lobe mass lesions. This represents a retrospective cohort study. Neurological decline was defined as a decline in Glasgow Coma Scale of 2 or more or new anisocoria. Adult patients aged 18 to 89 years with isolated temporal lobe, intra-axial, contrast-enhancing masses diagnosed between 1/1/2010 and 12/31/2020 were included. Clinical and radiographic findings were collected for each patient. Linear regression analysis was used to identify findings predictive of neurological decline. Patients with neurological decline were compared to stable patients to identify factors that may increase risk for neurological decline. A total of 71 patients met the inclusion criteria. Four out of the 71 patients experienced neurological decline, representing an incidence of 6%. Linear regression analysis identified only radiographic transtentorial herniation as a predictor of neurological decline (β=0.26, p=0.03). A midline shift greater than 5 mm (100% vs. 40%; odds ratio=1.12, 95% confidence interval=1.00-1.32; p=0.05) and radiographic transtentorial herniation (75% vs. 18%; odds ratio=32.12, 95% confidence interval=3.91-264.18; p=0.03) were significantly more prevalent in patients with neurological decline and were associated with an increased risk of neurological decline. Radiographic transtentorial herniation and a midline shift greater than 5 mm may be useful findings to suggest an increased risk of neurological decline in patients with masses of the temporal lobe. This knowledge may be useful to neurosurgeons and physicians in other specialties to best care for this patient population.