Differentiation of mesenchymal stem cell in the microenviroment of retinitis pigmentosa

CORRESPONDENCE TO: Fang-Tian Dong. Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. d_fangtian@sina.com To access the differentiation of rat mesenchymal stem cell (MSC) in the microenvironment of retinal degeneration indu...

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Published inInternational journal of ophthalmology Vol. 3; no. 3; pp. 216 - 219
Main Authors Huo, Dong-Mei, Dong, Fang-Tian, Yu, Wei-Hong, Gao, Fei
Format Journal Article
LanguageEnglish
Published China International Journal of Ophthalmology Press 2010
Subjects
Basic Research
transplantation in subretinal space
mesenchymal stem cell
NaIO3
retinal degeneration
differentiation
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Summary:CORRESPONDENCE TO: Fang-Tian Dong. Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. d_fangtian@sina.com To access the differentiation of rat mesenchymal stem cell (MSC) in the microenvironment of retinal degeneration induced by the administration of sodium iodate. In-vitro cultured Lewis rat MSC were injected into the sub-retinal space of NaIO(3) induced retinal degeneration rat eyes (30g/L NaIO(3) 100mg/kg). To observe the trace and differentiation of MSC by immuno-fluorescent method successively in 5 weeks after the surgery. The majority of the transplanted cells stay in retinal pigment epithelium layer and cones & rods layer. From the 2(nd) week after transplantation, the engrafted MSC express PCK and rhodopsin under fluorescent microscope. MSC can survive mainly in the outer layer of retina in the microenvironment of retinal degeneration and differentiate forward the RPE cell and photoreceptor.
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ISSN:2222-3959
2222-3959
DOI:10.3980/j.issn.2222-3959.2010.03.08