Asperenone: an inhibitor of 15-lipoxygenase and of human platelet aggregation from Aspergillus niger

Asperenone was isolated from the fermented broth of Aspergillus niger CFTRI 1105 and acted as an inhibitor of soybean 15-lipoxygenase (15-LOX) and human platelet aggregation. The IC^sub 50^ values against 15-LOX and human platelet aggregation were 0.3 mM and 0.23 mM, respectively.[PUBLICATION ABSTRA...

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Published inBiotechnology letters Vol. 24; no. 23; pp. 1967 - 1970
Main Authors SEKHAR RAN, K. C, DIVAKAR, S, APPU RAO, A. G, KARANTH, N. G, SUNEETHA, W. J, KRISHNAKANTHA, T. P, SATTUR, A. P
Format Journal Article
LanguageEnglish
Published Dordrecht Springer 01.12.2002
Springer Nature B.V
Subjects
Biological and medical sciences
Biotechnology
Cardiovascular disease
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Other active biomolecules
Production of active biomolecules
Human
asperenone
Enzyme
Fungi
Aggregation
Platelet
Aspergillus niger
human platelet aggregation
fermentation
Inhibitor
Fungi Imperfecti
Oxidoreductases
Lipoxygenase
Thallophyta
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Summary:Asperenone was isolated from the fermented broth of Aspergillus niger CFTRI 1105 and acted as an inhibitor of soybean 15-lipoxygenase (15-LOX) and human platelet aggregation. The IC^sub 50^ values against 15-LOX and human platelet aggregation were 0.3 mM and 0.23 mM, respectively.[PUBLICATION ABSTRACT]
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0141-5492
1573-6776
DOI:10.1023/A:1021125731940