Observations Made in Exploring a Pyridinium Salt Photochemical Approach to the Synthesis of (+)-Lactacystin

The key step in a strategy for the synthesis of (+)-lactacystin involving photocyclization reaction of a cyclopenta-fused pyridinium salt has been probed by using a model substrate. Observations made in this effort led to the discovery of a highly unusual cascade process that leads to stereoselectiv...

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Bibliographic Details
Published inBulletin of the Korean Chemical Society Vol. 29; no. 1; pp. 89 - 93
Main Authors Jiwen Zhou, 윤웅찬, Maozhen Gong, Patrick S. Mariano
Format Journal Article
LanguageEnglish
Published 대한화학회 20.01.2008
Subjects
화학
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Summary:The key step in a strategy for the synthesis of (+)-lactacystin involving photocyclization reaction of a cyclopenta-fused pyridinium salt has been probed by using a model substrate. Observations made in this effort led to the discovery of a highly unusual cascade process that leads to stereoselective formation of an interesting tricyclic carbamate. The results of this study are presented and discussed in the context of a (+)-lactacystin synthetic approach. KCI Citation Count: 5
Bibliography:G704-000067.2008.29.1.031
ISSN:0253-2964
1229-5949
DOI:10.5012/bkcs.2008.29.1.089