The Evolution of New Catalytic Mechanisms for Xenobiotic Hydrolysis in Bacterial Metalloenzymes

An increasing number of bacterial metalloenzymes have been shown to catalyse the breakdown of xenobiotics in the environment, while others exhibit a variety of promiscuous xenobiotic-degrading activities. Several different evolutionary processes have allowed these enzymes to gain or enhance xenobiot...

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Bibliographic Details
Published inAustralian journal of chemistry Vol. 69; no. 12; pp. 1383 - 1395
Main Authors Sugrue, Elena, Hartley, Carol J, Scott, Colin, Jackson, Colin J
Format Journal Article
LanguageEnglish
Published 01.01.2016
Subjects
Bacteria
Breakdown
Catalysis
Catalysts
Enzymes
Evolution
Gain
Hydrolysis
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Summary:An increasing number of bacterial metalloenzymes have been shown to catalyse the breakdown of xenobiotics in the environment, while others exhibit a variety of promiscuous xenobiotic-degrading activities. Several different evolutionary processes have allowed these enzymes to gain or enhance xenobiotic-degrading activity. In this review, we have surveyed the range of xenobiotic-degrading metalloenzymes, and discuss the molecular and catalytic basis for the development of new activities. We also highlight how our increased understanding of the natural evolution of xenobiotic-degrading metalloenzymes can be been applied to laboratory enzyme design.
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ISSN:0004-9425
1445-0038
DOI:10.1071/CH16426