Measurement of renal functional reserve in children

Renal functional reserve was measured during 89 studies in 78 children as the difference between the baseline glomerular filtration rate (GFR) and that following a protein meal. GFR was measured using creatinine as the filtration marker in children pre-treated with cimetidine. The children had been...

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Published inPediatric nephrology (Berlin, West) Vol. 19; no. 10; pp. 1132 - 1136
Main Authors Hellerstein, Stanley, Berenbom, Max, Erwin, Pat, Wilson, Nancy, DiMaggio, Sylvia
Format Journal Article
LanguageEnglish
Published Germany Springer Nature B.V 01.10.2004
Subjects
Adolescent
Adult
Bladder
Body composition
Child
Child, Preschool
Children & youth
Creatinine
Dietary Proteins - metabolism
Female
Glomerular Filtration Rate - physiology
Hemodynamics
Humans
Kidney - physiology
Kidney - physiopathology
Kidney diseases
Male
Nephrology
Patients
Proteins
Urine
Urologic Diseases - physiopathology
United States > US
Kansas City Missouri
Missouri
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Summary:Renal functional reserve was measured during 89 studies in 78 children as the difference between the baseline glomerular filtration rate (GFR) and that following a protein meal. GFR was measured using creatinine as the filtration marker in children pre-treated with cimetidine. The children had been on a diet free of meat, fish, and fowl for 24 h. The protein meal to stimulate GFR was derived from milk, cheese, eggs, and baked goods. The increase in GFR following the protein meal was due mainly to an increase in the glomerular filtration of creatinine, with a small contribution by decreased serum creatinine concentration. This study confirmed that renal functional reserve can be measured using a meat-free protein meal to stimulate GFR. The protocol employed is a relatively noninvasive and inexpensive procedure for identifying glomerular hyperfiltration in children.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-004-1550-9