Revisiting Repurposing

Drug repurposing can be a cost-effective strategy to identify new small molecule-based therapies. Thus, drug repurposing significantly influences the discovery of therapeutics, particularly for rare and neglected diseases, which are often constrained by limited research and development funds. The pu...

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Bibliographic Details
Published inAssay and drug development technologies Vol. 14; no. 10; p. 554
Main Author Sharlow, Elizabeth R
Format Journal Article
LanguageEnglish
Published United States 01.12.2016
Subjects
Animals
Drug Approval - methods
Drug Discovery - methods
Drug Discovery - trends
Drug Repositioning - methods
Drug Repositioning - trends
Humans
United States
drug library
drug rescue
drug repurposing
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Summary:Drug repurposing can be a cost-effective strategy to identify new small molecule-based therapies. Thus, drug repurposing significantly influences the discovery of therapeutics, particularly for rare and neglected diseases, which are often constrained by limited research and development funds. The push for translational science and access to drug discovery-associated resources such as high throughput screening instrumentation, assay development expertise, and Food and Drug Administration-approved drug libraries have intensified interest in drug repurposing. However, successful drug repurposing is highly challenging and subject to particular limitations. Despite these challenges, drug repurposing is a critical component to any comprehensive drug discovery strategy and has the capacity to benefit a wide variety of therapeutically underserved diseases.
ISSN:1557-8127
DOI:10.1089/adt.2016.766