MicroRNA-Dependent Regulation of IGF1R Gene Expression in Hormone-Sensitive and Hormone-Resistant Prostate Cancer Cells

Using multiple parallel sequencing on Illumina platform, we identified eight microRNAs that showed significant opposite changes of gene expression in cells of the hormone-sensitive LNCaP prostate cancer cell line and in cells of the hormone-resistant DU-145 cell line, in comparison to the microRNA e...

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Published inDoklady. Biochemistry and biophysics Vol. 479; no. 1; pp. 101 - 104
Main Authors Tarasov, V. A., Tyutyakina, M. G., Makhotkin, M. A., Shin, E. F., Naboka, A. V., Mashkarina, A. N., Chebotarev, D. A., Cherkasova, E. N., Kogan, M. I., Chibichyan, M. B., Matishov, D. G.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.03.2018
Springer Nature B.V
Subjects
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Gene expression
Insulin
Insulin-like growth factor I receptors
Life Sciences
MicroRNAs
miRNA
Molecular Biology
Prostate cancer
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Summary:Using multiple parallel sequencing on Illumina platform, we identified eight microRNAs that showed significant opposite changes of gene expression in cells of the hormone-sensitive LNCaP prostate cancer cell line and in cells of the hormone-resistant DU-145 cell line, in comparison to the microRNA expression in the normal prostate tissue cells. We found that the insulin-like growth factor 1 receptor ( IGF1R ) gene is a target of five microRNAs whose expression is increased in LNCaP cells and reduced in DU-145 cells.
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ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672918020138