Cutibacterium acnes Dysbiosis: Alternative Therapeutics for Clinical Application

Cutibacterium acnes (C. acnes) is a Gram-positive anaerobic facultative bacterium that is part of the human skin commensal microbiome. It colonizes various regions of the body, including the face, back, and chest. While typically a harmless commensal, under certain conditions, C. acnes can become pa...

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Published inApplied sciences Vol. 13; no. 21; p. 12086
Main Authors Sá, Sara, Fernandes, Ruben, Gestoso, Álvaro, Macedo, José Mário, Martins-Mendes, Daniela, Pereira, Ana Cláudia, Baylina, Pilar
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.11.2023
Subjects
Acne
antibiotic resistance
Antibiotics
Bacteria
Bacterial infections
Biofilms
Cancer therapies
Cutibacterium acnes
Endocarditis
Health care
Infections
Inflammation
Lipids
Microorganisms
Patients
personalized medicine
phage therapy
Prostate cancer
Skin
Surgery
Virulence
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Summary:Cutibacterium acnes (C. acnes) is a Gram-positive anaerobic facultative bacterium that is part of the human skin commensal microbiome. It colonizes various regions of the body, including the face, back, and chest. While typically a harmless commensal, under certain conditions, C. acnes can become pathogenic, leading to or promoting conditions such as acne vulgaris (AV), post-surgical infections, prostate cancer, and sarcoidosis. Current treatments for C. acnes infections often involve antibiotics, but the rise of antibiotic resistance has raised concerns. This review presents the virulence factors, clinical relevance, and current treatments of C. acnes, highlighting its association with AV, post-surgical infections, and other diseases. It also explores alternative innovative therapies such as phage therapy in development/research that are gaining prominence, with a growing focus on personalized medical approaches. To enhance C. acnes treatment while minimizing side effects and antibiotic prescription concerns, numerous clinical studies have been undertaken. These investigations span various pathological profiles and employ diverse strategies, such as utilizing bacterial extracts and compounds to restore healthy skin flora. The limitations and challenges of current and innovative treatments are also addressed, emphasizing the need for multidisciplinary strategies to combat C. acnes infections effectively.
ISSN:2076-3417
2076-3417
DOI:10.3390/app132112086