Cell-mediated immune response in head and neck cancer patients

The immune reactivity of 100 head and neck cancer patients was studied by means of DNCB, candidine, blastic transformation with PHA, and lymphocyte counts. DNCB reactivity was strong in only 21% of the population and was found impaired in patients with advanced primitive tumors, with more than one p...

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Bibliographic Details
Published inJournal of surgical oncology Vol. 8; no. 4; p. 287
Main Authors Olivari, A, Pradier, R, Feierstein, J, Guardo, A, Glait, H, Rojas, A
Format Journal Article
LanguageEnglish
Published United States 1976
Subjects
Aged
Antifungal Agents
Candida albicans - immunology
Dinitrochlorobenzene - immunology
Female
Head and Neck Neoplasms - immunology
Head and Neck Neoplasms - radiotherapy
Humans
Immunity, Cellular - radiation effects
Leukocyte Count
Lymphatic Metastasis
Lymphocyte Activation
Lymphocytes - immunology
Male
Middle Aged
Neoplasms, Multiple Primary - immunology
Polyenes
Radiation Effects
Skin Tests
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Summary:The immune reactivity of 100 head and neck cancer patients was studied by means of DNCB, candidine, blastic transformation with PHA, and lymphocyte counts. DNCB reactivity was strong in only 21% of the population and was found impaired in patients with advanced primitive tumors, with more than one primitive tumor, and in patients after radiation. Candidine reactivity was impaired in bigger primitive tumors, positive nodes, and advanced stages, as well as in postradiation patients. Blastic transformation was significantly worse in patients over 70 years and tended to be lower in patients with more than one primitive tumor. Good blastic transformation was also lowered in postradiation patients.
ISSN:0022-4790
DOI:10.1002/jso.2930080405