HAEMODYNAMIC EFFECTS OF LABETALOL-INDUCED HYPOTENSION IN THE ANAESTHETIZED DOG
Central haemodynamic changes and regional blood flow were studied using the microsphere technique, during labetalol-induced hypotension in dogs anaesthetized with pentobarbitone and fentanyl. Labetalol 15 mg kg−1 decreased mean arterial pressure from an average of 88 mm Hg to 47 mm Hg. Mean pulmonar...
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| Published in | British journal of anaesthesia : BJA Vol. 53; no. 6; pp. 585 - 590 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.06.1981
Oxford University Press |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Central haemodynamic changes and regional blood flow were studied using the microsphere technique, during labetalol-induced hypotension in dogs anaesthetized with pentobarbitone and fentanyl. Labetalol 15 mg kg−1 decreased mean arterial pressure from an average of 88 mm Hg to 47 mm Hg. Mean pulmonary arterial pressure was unchanged. Cardiac output was reduced by decrease in stroke volume, while heart rate remained unchanged. Myocardial blood flow decreased approximately in parallel with left ventricular work. Perfusion of the brain and kidneys was unchanged. |
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| AbstractList | Central haemodynamic changes and regional blood flow were studied using the microsphere technique, during labetalol-induced hypotension in dogs anaesthetized with pentobarbitone and fentanyl. Labetalol 15 mg kg-1 decreased mean arterial pressure from an average of 88 mm Hg to 47 mm Hg. Mean pulmonary arterial pressure was unchanged. Cardiac output was reduced by decrease in stroke volume, while heart rate remained unchanged. Myocardial blood flow decreased approximately in parallel with left ventricular work. Perfusion of the brain and kidneys was unchanged. Central haemodynamic changes and regional blood flow were studied using the microsphere technique, during labetalol-induced hypotension in dogs anaesthetized with pentobarbitone and fentanyl. Labetalol 15 mg kg−1 decreased mean arterial pressure from an average of 88 mm Hg to 47 mm Hg. Mean pulmonary arterial pressure was unchanged. Cardiac output was reduced by decrease in stroke volume, while heart rate remained unchanged. Myocardial blood flow decreased approximately in parallel with left ventricular work. Perfusion of the brain and kidneys was unchanged. |
| Author | AHLGREN, I. GUSTAFSON, C. ARONSEN, K.F. ROSEBERG, B. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/7248122$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Animals Coronary Circulation - drug effects Dogs Dose-Response Relationship, Drug Ethanolamines - pharmacology Hemodynamics - drug effects Hypotension, Controlled Labetalol - blood Labetalol - pharmacology Regional Blood Flow - drug effects |
| Title | HAEMODYNAMIC EFFECTS OF LABETALOL-INDUCED HYPOTENSION IN THE ANAESTHETIZED DOG |
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