HAEMODYNAMIC EFFECTS OF LABETALOL-INDUCED HYPOTENSION IN THE ANAESTHETIZED DOG

Central haemodynamic changes and regional blood flow were studied using the microsphere technique, during labetalol-induced hypotension in dogs anaesthetized with pentobarbitone and fentanyl. Labetalol 15 mg kg−1 decreased mean arterial pressure from an average of 88 mm Hg to 47 mm Hg. Mean pulmonar...

Full description

Saved in:
Bibliographic Details
Published inBritish journal of anaesthesia : BJA Vol. 53; no. 6; pp. 585 - 590
Main Authors GUSTAFSON, C., AHLGREN, I., ARONSEN, K.F., ROSEBERG, B.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.1981
Oxford University Press
Subjects
Animals
Coronary Circulation - drug effects
Dogs
Dose-Response Relationship, Drug
Ethanolamines - pharmacology
Hemodynamics - drug effects
Hypotension, Controlled
Labetalol - blood
Labetalol - pharmacology
Regional Blood Flow - drug effects
Online AccessGet full text

Cover

More Information
Summary:Central haemodynamic changes and regional blood flow were studied using the microsphere technique, during labetalol-induced hypotension in dogs anaesthetized with pentobarbitone and fentanyl. Labetalol 15 mg kg−1 decreased mean arterial pressure from an average of 88 mm Hg to 47 mm Hg. Mean pulmonary arterial pressure was unchanged. Cardiac output was reduced by decrease in stroke volume, while heart rate remained unchanged. Myocardial blood flow decreased approximately in parallel with left ventricular work. Perfusion of the brain and kidneys was unchanged.
Bibliography:ark:/67375/HXZ-GR7TXXBK-P
istex:724F49968E861508D4E2EC0C222CEF5789E2D8D0
ArticleID:53.6.585
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/53.6.585