Molecular Dynamics Simulation from Symmetry Breaking Changing to Asymmetrical Phospholipid Membranes Due to Variable Capacitors during Resonance with Helical Proteins

• Published in: Symmetry (Basel) Vol. 15; no. 6; p. 1259
• Main Authors: Thi Dang, Dung, Monajjemi, Majid, Mollaamin, Fatemeh, Dang, Chien
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.06.2023
• Subjects: Asymmetry; Broken symmetry; Capacitors; Electronic components industry; Lipids; Membrane structures; Membranes; Molecular dynamics; Phosphates; Phospholipids; Phosphors; Potential gradient; Proteins; Symmetry
• ISSN: 2073-8994; 2073-8994
• DOI: 10.3390/sym15061259

Biological symmetry breaking is a mechanism in biosystems that is necessary for human survival, and depends on chemical physics concepts at both microscopic and macroscopic scales. In this work, we present a few mechanisms of the signaling phenomenon that have been studied in various tissues of human origin. We exhibit that anatomical asymmetry in the structure of a membrane can produce a flow of extracellular fluid. Furthermore, we exhibit that membrane asymmetry is a misbalance in the composition of the aqueous phases and interaction forces with the protein trans-membrane. Various biological membranes such as DPPC, DMPC, DLPC, and so on, have considerable electrostatic voltages that extend across the phosphor lipids bilayer. For studying these phenomena, we modeled DPPC, DMPC, and DLPC lipid bilayers with a net charge misbalance across the phospholipids. Because asymmetric membranes create the shifted voltages among the various aqueous tissues, this effect makes the charge misbalances cause a voltage of 1.3 V across the DPPC bilayer and 0.8 V across the DMPC bilayer. This subject exhibits the importance of membrane structures on electrostatic potential gradients. Finally, we exhibited that a quantum effect was created in small parts of the cell’s thickness due to the symmetry breaking of asymmetrical phospholipid bilayers.