Non-coding RNAs: the riddle of the transcriptome and their perspectives in cancer

Non-coding RNAs (ncRNAs) constitute a heterogeneous group of RNA molecules in terms of biogenesis, biological function as well as length and structure. These biological molecules have gained attention recently as a potentially crucial layer of tumor cell progression or regulation. ncRNAs are express...

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Published inAnnals of translational medicine Vol. 6; no. 12; p. 241
Main Authors Diamantopoulos, Marios A, Tsiakanikas, Panagiotis, Scorilas, Andreas
Format Journal Article
LanguageEnglish
Published China AME Publishing Company 01.06.2018
Subjects
Review on Biomarkers/Molecular Diagnostic Tools
transcriptomics
Biomarker
small non-coding RNA (sncRNA)
long non-coding RNA (lncRNA)
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Summary:Non-coding RNAs (ncRNAs) constitute a heterogeneous group of RNA molecules in terms of biogenesis, biological function as well as length and structure. These biological molecules have gained attention recently as a potentially crucial layer of tumor cell progression or regulation. ncRNAs are expressed in a broad spectrum of tumors, and they play an important role not only in maintaining but also in promoting cancer development and progression. Recent discoveries have revealed that ncRNAs may act as key signal transduction mediators in tumor signaling pathways by interacting with RNA or proteins. These results reinforce the hypothesis, that ncRNAs constitute therapeutic targets, and point out their clinical potential as stratification markers. The major purpose of this review is to mention the emergence of the importance of ncRNAs, as molecules which are correlated with cancer, and to discuss their clinical implicit as prognostic diagnostic indicators, biomarkers, and therapeutic targets.
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Contributions: (I) Conception and design: All authors; (II) Administrative support: A Scorilas; (III) Provision of study materials or patients: All authors; (IV) Collection and assembly of data: MA Diamantopoulos, P Tsiakanikas; (V) Data analysis and interpretation: MA Diamantopoulos, P Tsiakanikas; (VI) Manuscript writing: All authors ; (VII) Final approval of manuscript: All authors.
ISSN:2305-5839
2305-5839
DOI:10.21037/atm.2018.06.10