Cortical Spreading Depression and Ischemia in Neurocritical Patients

Spreading depolarization in cerebral cortex is associated with swelling of neurons, distortion of dendritic spines, massive ion translocation with a large change of the slow electrical potential, and silencing of brain electrical activity. The term spreading depression represents a wave of spontaneo...

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Bibliographic Details
Published inNeurosurgery clinics of North America Vol. 29; no. 2; p. 223
Main Authors Wainsztein, Néstor, Rodríguez Lucci, Federico
Format Journal Article
LanguageEnglish
Published United States 01.04.2018
Subjects
Delayed cerebral ischemia
Stroke
Spreading depolarization
Cerebral blood flow
Subarachnoid hemorrhage
Cortical spreading depression
Spreading ischemia
Spreading depression
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Summary:Spreading depolarization in cerebral cortex is associated with swelling of neurons, distortion of dendritic spines, massive ion translocation with a large change of the slow electrical potential, and silencing of brain electrical activity. The term spreading depression represents a wave of spontaneous activity of the electrocorticogram that propagates through contiguous cerebral gray matter at a characteristic velocity. Spreading depression is a consequence of cortical spreading depolarization. Therefore, spreading depolarization is not always accompanied by spreading depression and the terms are not synonymous.
ISSN:1558-1349
DOI:10.1016/j.nec.2017.11.003