Diabetes-related end-stage renal disease in Austria 1965-2013

• Published in: Nephrology, dialysis, transplantation Vol. 30; no. 11; pp. 1920 - 1927
• Main Authors: Prischl, Friedrich C, Auinger, Martin, Säemann, Marcus, Mayer, Gert, Rosenkranz, Alexander R, Wallner, Manfred, Kramar, Reinhard
• Format: Journal Article
• Language: English
• Published: England 01.11.2015
• Subjects: Adult; Aged; Austria - epidemiology; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - physiopathology; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - physiopathology; Diabetic Nephropathies - etiology; Female; Humans; Incidence; Kidney Failure, Chronic - etiology; Male; Middle Aged; Prevalence; Registries; Renal Dialysis; Time Factors; Austria; diabetic kidney disease; end-stage renal disease; incidence; diabetic nephropathy; survival probability
• ISSN: 0931-0509; 1460-2385
• DOI: 10.1093/ndt/gfv113

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) in Austria, accounting for a high burden of morbidity and mortality. In this nationwide study, we aimed to evaluate the incidence and fate of patients with DKD-ESRD over time. Data (collected annually) from the Austrian Dialysis- and Transplant Registry were analysed for the development of ESRD due to DKD from 1965 to 2013. Over 48 years, 8322 and 22 975 patients with ESRD due to diabetes and non-diabetes, respectively, entered dialysis. While DKD-ESRD-patients were not dialysed until 1974, in 1975 seven type 1- and one type 2-diabetics started dialysis (1.06 per million population-PMP). In the mid-eighties, DKD-ESRD-patients increasingly were accepted for dialysis (1986: 14.53 PMP, 1996: 31.16 PMP). After a peak incidence of 415 diabetic ESRD-patients in 2006 (50.19 PMP), numbers decreased continuously thereafter (2013: 299 patients, 35.73 PMP). Mean age at start of dialysis increased over time and was lower in type 1- and higher in type 2- compared with non-diabetic patients. Five-year-survival-probability in two diabetic ESRD-cohorts, starting in 2007/08 and 10 years earlier was calculated. Five-year-survival was 28% in 1997/98 and 37.5% in 2007/08. Adjusted relative risk reduction was 33% (HR 0.67, CI 95% 0.57-0.78; P < 0.001). Despite a growing prevalence of diabetes, the incidence of diabetic ESRD has decreased after 2006. Five-year-survival-probability has improved over 10 years. Multifactorial therapeutic interventions may have resulted in this improvement.