Clinical Outcome of Pipeline Embolization Device with and without Coils to Treat Intracranial Aneurysm: A Systematic Review and Meta-Analysis

• Published in: American journal of neuroradiology : AJNR Vol. 46; no. 2; pp. 272 - 277
• Main Authors: Kesumayadi, Irfan, Sakamoto, Makoto, Hosoya, Tomohiro, Kambe, Atsushi, Uno, Tetsuji, Yoshioka, Hiroki, Kurosaki, Masamichi
• Format: Journal Article
• Language: English
• Published: United States 01.02.2025
• Subjects: Embolization, Therapeutic - instrumentation; Embolization, Therapeutic - methods; Humans; Intracranial Aneurysm - therapy; Postoperative Complications - epidemiology; Treatment Outcome
• ISSN: 0195-6108; 1936-959X; 1936-959X
• DOI: 10.3174/ajnr.A8443

The use of a Pipeline Embolization Device (PED) in combination with coils (PEDC) to treat intracranial aneurysms remains unclear as to whether it offers significant benefits for the patients because the results have varied. This study aimed to investigate the clinical outcome of the PEDC compared with the PED in treating intracranial aneurysms. We systematically searched the articles from PubMed, Web of Science, and the Cochrane Library databases published before January 25, 2024. We selected studies comparing the PEDC versus the PED to treat intracranial aneurysms. Patients treated with the PEDC but using dense coiling were excluded from the study. The clinical outcomes observed in this meta-analysis were intraprocedural complications, postoperative complications (stenosis, stroke, hemorrhage, mortality), favorable outcome (mRS ≤2), complete occlusion rate, and retreatment rate. A forest plot was used to analyze pooled OR of clinical outcomes. A total of 3001 subjects from 9 observational studies were included. The PEDC was mainly used to treat larger aneurysms. The PEDC has a significantly higher complete occlusion rate at 6 months (OR = 2.66; 95% CI, 1.26-115.59; = .01), a lower retreatment rate (OR = 0.18; 95% CI, 0.05-0.07; = .010), higher stroke-related complications (OR= 1.66, 95% CI, 1.16-2.37; = .005), and higher hemorrhage-related complications (OR = 1.98; 95% CI, 1.22-13.21; = .005). There was no significant difference in intraprocedural complications, stenosis-related complications, mortality, favorable outcomes, and complete occlusion at the end of the study. No randomized controlled trials have been performed comparing the PEDC and PED. Considering that all the included studies were observational, the patients' baseline characteristics were not completely balanced. This meta-analysis study showed that the PEDC in large intracranial aneurysms induces a faster complete occlusion rate at 6 months and a lower retreatment rate. However, it increases the risk of stroke-related postoperative complications, and the faster complete aneurysm occlusion rate found in this study did not correlate with a reduction in long-term aneurysm or distal artery ruptures. Thus, this study suggests the need to find a better strategy to improve long-term hemorrhage-related complications in large intracranial aneurysms.