Is There Any Association Between Triglyceride–Glucose Index and Graft Function in Kidney Transplant Recipients?

• Published in: Transplantation proceedings Vol. 55; no. 2; pp. 346 - 349
• Main Authors: Şirin, Mehmet Emin, Yılmaz, Mehmet, Polat, Muhammed Emin, Karaaslan, Mustafa, Ölçücüoğlu, Esin, Ölçücüoğlu, Erkan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2023
• Subjects: Creatinine; Glomerular Filtration Rate; Glucose; Humans; Kidney; Kidney Transplantation - adverse effects; Male; Prospective Studies; Retrospective Studies
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2023.01.016

•Research has shown that insulin resistance (IR) and chronic kidney disease share a close relationship through a hyperglycemic state.•The triglyceride–glucose index (TyGi), which is less expensive and easier to calculate than the homeostatic model assessment of IR, was developed to represent IR. Studies in the literature have indicated an association between IR and many diseases, including impaired renal function. Nonetheless, the relationship between the TyGi and graft function remains a matter of curiosity.•We found that the TyGi, an easy and inexpensive marker of IR, was not associated with graft function at the postoperative months 1, 6, and 12 in kidney transplant patients. Although previous studies have illustrated the relationship between chronic kidney disease, coronary artery disease, erectile dysfunction, and the triglyceride–glucose index (TyGi), the relationship between this index and postoperative graft function in patients undergoing renal transplantation has yet to be investigated. In the present study, we aimed to reveal the association between the TyGi and renal graft outcomes in patients who underwent renal transplantation. We retrospectively collected data on living and cadaveric kidney donor recipients between May 2019 and April 2022. The recipients’ age, sex, body mass index, preoperative fasting glucose and triglyceride levels, TyGi, estimated glomerular filtration rate (eGFR), and serum creatinine measurement data were recorded. The patients were divided into 2 groups according to their GFR values (group 1: GFR <60 mL/min/1.73 m2; group 2: GFR ≥60 mL/min/1.73 m2). Follow-up serum creatinine–eGFR levels and TyGi measurements were compared between the recipients in group 1 and group 2. The mean TyGi measurements of the recipients were 8.79 ± 0.64 in group 1 and 8.83 ± 0.72 in group 2. There was no statistically significant difference in terms of the TyGi measurements between the 2 groups (P >. 05). No statistically significant correlation was found between the recipients’ creatinine, eGFR, and TyGi at 1st, 6th, and 12th postoperative months (P > .05). We believe that the relationship between the TyGi and renal graft function can be more clearly understood in prospective studies that include a higher number of patients and a longer follow-up period.