Expression and prognostic potential of GPX1 in human cancers based on data mining

• Published in: Annals of translational medicine Vol. 8; no. 4; p. 124
• Main Authors: Wei, Ruqiong, Qiu, Hongtu, Xu, Jianwen, Mo, Juanmei, Liu, Ying, Gui, Yuchang, Huang, Guangyou, Zhang, Shunrong, Yao, Hongfang, Huang, Xiaoxiao, Gan, Zhichuan
• Format: Journal Article
• Language: English
• Published: China AME Publishing Company 01.02.2020
• Subjects: Original; prognostic biomarker; carcinogenensis; Glutathione peroxidase-1 (GPX1); methylation
• ISSN: 2305-5839; 2305-5839
• DOI: 10.21037/atm.2020.02.36

Glutathione peroxidase-1 (GPX1) is a member of the GPX family, which considered an enzyme that interacts with oxidative stress. GPX1 differential expression is closely correlated with carcinogenesis and disease progression. In this study, we used bioinformatics analysis to investigate GPX1 expression level and explore the prognostic information in different human cancers. Expression was analyzed via the Oncomine database and Gene Expression Profiling Interactive Analysis tool, and potential prognostic analysis was evaluated using the UALCAN, GEPIA, and DriverDBv3 databases. Then, the UALCAN database was used to find the promoter methylation of GPX1 in defied cancer types. While GPX1 related functional networks were found within the GeneMANIA interactive tool and Cytoscape software. Moreover, Metascape online website was used to analyze Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways. We found that GPX1 was commonly overexpressed in most human cancers. High expression of GPX1 could lead to poor outcomes in Brain Lower Grade Glioma, while GPX1 over expression was correlated with better prognosis in Kidney renal papillary cell carcinoma (KIPP). High GPX1 expression was marginally associated with poor prognosis in acute myeloid leukemia (AML). Gene regulation network suggested that GPX1 mainly involved in pathways including the glutathione metabolism, ferroptosis, TP53 regulates metabolic genes, reactive oxygen species (ROS) metabolic process, and several other signaling pathways. Our findings revealed that GPX1 showed significant expression differences among cancers and served as a prognostic biomarker for defined cancer types. The data mining effectively revealed useful information about GPX1 expression, prognostic values, and potential functional networks in cancers, thus providing researchers with an available way to further explore the mechanism underlying carcinogenesis of genes of interest in different cancers.