Renohepatic crosstalk: does acute kidney injury cause liver dysfunction?

The concept of hepatorenal syndrome is well recognized, although incompletely understood. The converse clinical problem of hepatic dysfunction in patients with acute kidney injury (AKI) is less well recognized yet may be a contributor to the high patient morbidity and mortality seen in this group. T...

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Bibliographic Details
Published inNephrology, dialysis, transplantation Vol. 28; no. 7; pp. 1634 - 1647
Main Authors Lane, Katie, Dixon, John J, MacPhee, Iain A M, Philips, Barbara J
Format Journal Article
LanguageEnglish
Published England 01.07.2013
Subjects
Acute Kidney Injury - complications
Acute Kidney Injury - therapy
Animals
Hepatorenal Syndrome - physiopathology
Humans
Liver Diseases - etiology
Liver Diseases - prevention & control
acute kidney injury
crosstalk
liver
drug metabolism
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Summary:The concept of hepatorenal syndrome is well recognized, although incompletely understood. The converse clinical problem of hepatic dysfunction in patients with acute kidney injury (AKI) is less well recognized yet may be a contributor to the high patient morbidity and mortality seen in this group. This review draws together the available evidence for AKI's effect on the liver from animal models, pharmacological studies and recent clinical data. It examines liver function beyond clinically used blood tests, to determine the effect of AKI on hepatic synthetic function, acute phase response and drug metabolism. Parallels are drawn with other organ crosstalk in AKI and with liver-kidney interactions in chronic kidney disease. Definition of the pathophysiology of renohepatic crosstalk may lead to improved management strategies for this vulnerable patient group.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gft091