Serum albumin enhances the membrane activity of ZnO nanoparticles

• Published in: Chemical communications (Cambridge, England) Vol. 49; no. 39; pp. 4172 - 4174
• Main Authors: Churchman, Adam H, Wallace, Rachel, Milne, Steven J, Brown, Andy P, Brydson, Rik, Beales, Paul A
• Format: Journal Article
• Language: English
• Published: England 14.05.2013
• Subjects: Animals; Cattle; Cell Membrane - chemistry; Cell Membrane - metabolism; Humans; Lipid Bilayers - chemistry; Lipid Bilayers - metabolism; MCF-7 Cells; Metal Nanoparticles - chemistry; Phosphatidylcholines - chemistry; Serum Albumin, Bovine - chemistry; Serum Albumin, Bovine - metabolism; Zinc Oxide - chemistry

We investigate the effect of serum albumin on the interaction of ZnO nanoparticles with DOPC lipid membranes and show that the size-stabilizing effect of the protein corona enhances their interaction with lipid membranes, which manifests, in part, as an increased ordering in the lipid packing.