Serum albumin enhances the membrane activity of ZnO nanoparticles

We investigate the effect of serum albumin on the interaction of ZnO nanoparticles with DOPC lipid membranes and show that the size-stabilizing effect of the protein corona enhances their interaction with lipid membranes, which manifests, in part, as an increased ordering in the lipid packing.

Saved in:
Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 49; no. 39; pp. 4172 - 4174
Main Authors Churchman, Adam H, Wallace, Rachel, Milne, Steven J, Brown, Andy P, Brydson, Rik, Beales, Paul A
Format Journal Article
LanguageEnglish
Published England 14.05.2013
Subjects
Animals
Cattle
Cell Membrane - chemistry
Cell Membrane - metabolism
Humans
Lipid Bilayers - chemistry
Lipid Bilayers - metabolism
MCF-7 Cells
Metal Nanoparticles - chemistry
Phosphatidylcholines - chemistry
Serum Albumin, Bovine - chemistry
Serum Albumin, Bovine - metabolism
Zinc Oxide - chemistry
Online AccessGet full text

Cover

More Information
Summary:We investigate the effect of serum albumin on the interaction of ZnO nanoparticles with DOPC lipid membranes and show that the size-stabilizing effect of the protein corona enhances their interaction with lipid membranes, which manifests, in part, as an increased ordering in the lipid packing.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc37871c