Lupus Nephritis: Varying Complement-Fixing Properties of Immunoglobulin G Antibodies to Antigens of Cell Nuclei

Relative complement-fixing activity of antibodies to nuclear antigens, including DNA, were determined in serums of 15 patients with, and 65 patients without, active lupus nephritis, by comparing titers obtained in two methods. High complement-fixing activity of antibody was found in the nephritis gr...

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Published inScience (American Association for the Advancement of Science) Vol. 161; no. 3844; pp. 904 - 906
Main Authors Tojo, Takeshi, Friou, George J.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 30.08.1968
Subjects
Antibodies
Antibodies, Antinuclear
Antigens
Antinuclear antibodies
Arthritis, Rheumatoid - immunology
Autoantibodies
Cell Nucleus - immunology
Complement Fixation Tests
DNA
Fluorescent Antibody Technique
gamma-Globulins
Glomerulonephritis
Glomerulonephritis - immunology
Hepatitis - immunology
Humans
Immunoglobulins
Lupus Erythematosus, Systemic - immunology
Lupus nephritis
Nephritis
Nuclear antigens
Systemic lupus erythematosus
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Summary:Relative complement-fixing activity of antibodies to nuclear antigens, including DNA, were determined in serums of 15 patients with, and 65 patients without, active lupus nephritis, by comparing titers obtained in two methods. High complement-fixing activity of antibody was found in the nephritis group and low activity in the others. Results with immunoglobulin G fractions were similar.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.161.3844.904