Role of DNA repair-related gene polymorphisms in susceptibility to risk of prostate cancer

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 14; no. 10; pp. 5839 - 5842
• Main Authors: Yang, Bo, Chen, Wei-Hua, Wen, Xiao-Fei, Liu, Hui, Liu, Feng
• Format: Journal Article
• Language: English
• Published: Thailand 01.01.2013
• Subjects: Aged; Alleles; Case-Control Studies; DNA Repair - genetics; Genetic Predisposition to Disease - genetics; Genotype; Humans; Male; Polymorphism, Single Nucleotide - genetics; Prostatic Neoplasms - genetics; Risk
• ISSN: 1513-7368; 2476-762X
• DOI: 10.7314/APJCP.2013.14.10.5839

We assessed the association between genetic variants of XPG, XPA, XPD, CSB, XPC and CCNH in the nucleotide excision repair (NER) pathway and risk of prostate cancer. We genotyped the XPG, XPA, XPD, CSB, XPC and CCNH polymorphisms by a 384-well plate format on the MassARRAY® platform. Multivariate logistical regression analysis was used to assess the associations between the six gene polymorphisms and risk of prostate cancer. Individuals carrying the XPG rs229614 TT (OR=2.01, 95%CI=1.35-3.27) genotype and T allele (OR=1.73, 95%CI=1.37-2.57) were moderately significantly associated with a higher risk of prostate cancer. Subjects with XPD rs13181 G allele had a marginally increased risk of prostate cancer, with adjusted OR(95%CI) of 1.53 (1.04-2.37). Moreover, individuals carrying with CSB rs2228526 GG genotype (OR=2.05, 95% CI=1.23-3.52) and G allele (OR=1.56, 95%CI=1.17-2.05) were associated with a higher increased risk of prostate cancer. The combination genotype of XPG rs2296147 T and CSB rs2228526 G allele had accumulative effect on the risk of this cancer, with an OR (95% CI) of 2.23(1.37-3.59). Our study indicates that XPG rs2296147 and CSB rs2228526 polymorphisms are significantly associated with increased risk of prostate cancer, and that combination of XPG rs2296147 T allele and CSB rs2228526 G allele is strongly associated with an increased risk.