Quantifying disease-specific symptom improvement after parathyroid and thyroid surgery using patient-reported outcome measures

• Published in: The American journal of surgery Vol. 224; no. 3; pp. 923 - 927
• Main Authors: Romero-Velez, Gustavo, Burneikis, Talia, Zolin, Samuel J., Noureldine, Salem I., Jin, Judy, Berber, Eren, Krishnamurthy, Vikram D., Shin, Joyce, Siperstein, Allan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2022; Elsevier Limited
• Subjects: Clinical outcomes; Hyperparathyroidism; Likert scale; Parathyroid hormone; Parathyroidectomy; Patient reported outcomes; Patients; Quality assessment; Quality of life; Signs and symptoms; Surgeons; Surgery; Thyroid; Thyroid diseases; Thyroidectomy; Thyroidectomy; Patient reported outcomes; Parathyroidectomy
• ISSN: 0002-9610; 1879-1883
• DOI: 10.1016/j.amjsurg.2022.04.033

Patient-reported outcome measures for parathyroid and thyroid disease (PROMPT) is a 30-question, previously validated, survey assessing symptoms on a scale from 0 to 100. Using PROMPT, we aimed to assess symptom improvement for patients undergoing thyroidectomy and parathyroidectomy. Single-center prospective study in which PROMPT was used to assess symptom improvement in patients undergoing parathyroidectomy or thyroidectomy. A postoperative assessment was performed approximately 6 months after surgery and compared to its baseline preoperative assessment. A total of 144 patients completed both assessments (71 parathyroidectomy, 73 thyroidectomy). Parathyroidectomy patients demonstrated significant improvements in all hyperparathyroidism domains (38.2–28.3, p < 0.001) regardless of preoperative calcium and parathyroid hormone levels. Thyroidectomy patients experienced improvement in their compressive symptoms (25.6–16.5, p < 0.001). PROMPT objectively demonstrates the clinical effectiveness of parathyroidectomy and thyroidectomy in alleviating subjective patient symptoms. PROMPT offers promising use as a standardized metric to assess quality of life improvement within endocrine surgery. •PROMPT can objectively demonstrate the clinical effectiveness of parathyroidectomy and thyroidectomy.•PROMPT can objectively demonstrate the clinical effectiveness of parathyroidectomy regardless of the biochemical profile.•PROMPT can help evaluate patients in a high-volume clinic with mixed thyroid and parathyroid disease states.