Aggressive B-Cell Lymphoma Involving the Appendix and Bilateral Ovaries in an 11-Year-Old Girl

The appendix and ovaries are rarely involved simultaneously in malignancies. The decision to perform an ovarian biopsy or a surgical resection in young patients can be challenging without sufficient clinical information. We describe an 11-year-old girl with bilateral ovarian masses, an enlarged appe...

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Published inJournal of pediatric & adolescent gynecology Vol. 33; no. 4; pp. 421 - 424
Main Authors Tsunogai, Toshiki, Yamaoka, Masayoshi, Ohyama, Wataru, Honda, Takaya, Kusuhara, Atsuko, Akiyama, Masaharu
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.2020
Subjects
Aggressive B-cell lymphoma
Appendix
Bilateral ovaries
Fertility sparing
Non-Hodgkin lymphoma
Non-Hodgkin lymphoma
Aggressive B-cell lymphoma
Fertility sparing
Bilateral ovaries
Appendix
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Summary:The appendix and ovaries are rarely involved simultaneously in malignancies. The decision to perform an ovarian biopsy or a surgical resection in young patients can be challenging without sufficient clinical information. We describe an 11-year-old girl with bilateral ovarian masses, an enlarged appendix, associated pleural effusion, and ascites. Appendectomy and biopsy of the bilateral ovarian masses led to a diagnosis of aggressive B-cell non-Hodgkin lymphoma. The patient was treated with chemotherapy, which achieved complete remission and bilateral ovarian preservation. If ovarian involvement in malignant lymphoma is suspected, diagnostic methods should spare the ovary and prevent a loss of fertility. To evaluate for possible chemotherapy-induced ovarian damage, including infertility and premature menopause, an interdisciplinary approach is needed for the long-term follow-up of adolescent girls.
ISSN:1083-3188
1873-4332
DOI:10.1016/j.jpag.2020.04.003