Impact of parenchyma-preserving surgical methods on treating patients with solid pseudopapillary neoplasms: A retrospective study with a large sample size

• Published in: World journal of gastrointestinal surgery Vol. 14; no. 2; pp. 174 - 184
• Main Authors: Li, Yu-Qiong, Pan, Shu-Bo, Yan, Shu-Shu, Jin, Zhen-Dong, Huang, Hao-Jie, Sun, Li-Qi
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 27.02.2022
• Subjects: Retrospective Study; Surgical resection; Solid pseudopapillary neoplasm; Parenchyma-preserving method; Pancreatic exocrine insufficiency
• ISSN: 1948-9366; 1948-9366
• DOI: 10.4240/wjgs.v14.i2.174

Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare neoplasm that mainly affects young women. To evaluate the impact of parenchyma-preserving surgical methods (PPMs, including enucleation and central pancreatectomy) in the treatment of SPN patients. From 2013 to 2019, patients who underwent pancreatectomy for SPNs were retrospectively reviewed. The baseline characteristics, intraoperative index, pathological outcomes, short-term complications and long-term follow-up data were compared between the PPM group and the conventional method (CM) group. In total, 166 patients were included in this study. Of them, 33 patients (19.9%) underwent PPM. Most of the tumors (104/166, 62.7%) were found accidentally. Comparing the parameters between groups, the hospital stay d (12.35 13.5 d, = 0.49), total expense (44213 54084 yuan, = 0.21), operation duration (135 120 min, = 0.71), and intraoperative bleeding volume (200 100 mL, = 0.49) did not differ between groups. Regarding pathological outcomes, tumor size (45 32 mm, = 0.07), Ki67 index ( = 0.53), peripheral tissue invasion (11.3% 9.1%, = 0.43) and positive margin status (7.5% 6%, = 0.28) also did not differ between groups. Moreover, PPM did not increase the risk of severe postoperative pancreatic fistula (3.8% 3.0%, = 0.85) or tumor recurrence (3.0% 6.0%, = 0.39). However, the number of patients who had exocrine insufficiency during follow-up was significantly lower in the PPM group (21.8% 3%, = 0.024). CM was identified as an independent risk factor for pancreatic exocrine insufficiency (odds ratio = 8.195, 95% confident interval: 1.067-62.93). PPM for SPN appears to be feasible and safe for preserving the exocrine function of the pancreas.