Post-transplant Monoclonal Gammopathy of Renal Significance: A Case Series

Monoclonal gammopathy of renal significance (MGRS) is a new concept with evolving evidence for treatment. MGRS in the transplant kidney is a rare cause of renal transplant dysfunction that can lead to graft loss. Most cases of post-transplant MGRS are due to recurrent disease. Clone-specific chemoth...

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Published inTransplantation proceedings Vol. 52; no. 3; pp. 857 - 864
Main Authors Rana, Ritika, Cockwell, Paul, Pratt, Guy, Cook, Mark, Drayson, Mark, Vydianath, Bindu, Neil, Desley, Pinney, Jennifer H.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2020
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Summary:Monoclonal gammopathy of renal significance (MGRS) is a new concept with evolving evidence for treatment. MGRS in the transplant kidney is a rare cause of renal transplant dysfunction that can lead to graft loss. Most cases of post-transplant MGRS are due to recurrent disease. Clone-specific chemotherapy is required to target the underlying clone, and this may improve graft survival; however, this can be challenging, as most patients are elderly with age-related comorbidities and may have complications associated with increasing immunosuppression. Here, we report 3 cases of renal allograft MGRS, and each case highlights different challenges in the diagnosis and management of this condition.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2019.12.040