Palladium-catalyzed allylic amination: a powerful tool for the enantioselective synthesis of acyclic nucleoside phosphonates

Acyclic nucleoside phosphonates have been prepared in a straightforward manner and in high yields by an enantioselective palladium-catalyzed allylic substitution involving nucleic bases as nucleophiles followed by cross-metathesis reaction with diethyl allylphosphonate.

Saved in:
Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 15; no. 34; pp. 7227 - 7234
Main Authors Azzouz, Mariam, Soriano, Sebastien, Escudero-Casao, Margarita, Isabel Matheu, M., Castillon, Sergio, Diaz, Yolanda
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 30.08.2017
Subjects
Alkenes - chemistry
Amination
Catalysis
Chemistry
Chemistry Techniques, Synthetic
Chemistry, Organic
Nucleosides - chemistry
Organophosphonates - chemical synthesis
Organophosphonates - chemistry
Palladium - chemistry
Physical Sciences
Science & Technology
CROSS-METATHESIS
RING-CLOSING METATHESIS
ALPHA,BETA-UNSATURATED KETONES
FORMAL SYNTHESIS
HETEROCYCLES
STRATEGY
COMPLEXES
CARBANUCLEOSIDES
DERIVATIVES
EFFICIENT
Online AccessGet full text

Cover

More Information
Summary:Acyclic nucleoside phosphonates have been prepared in a straightforward manner and in high yields by an enantioselective palladium-catalyzed allylic substitution involving nucleic bases as nucleophiles followed by cross-metathesis reaction with diethyl allylphosphonate.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob01478c