Concurrent gastric MALT and Hodgkin lymphoma: a case report

• Published in: International journal of surgical pathology Vol. 20; no. 2; p. 201
• Main Authors: Oka, Kuniyuki, Nagayama, Reizo, Yonekawa, Nobuo, Nihei, Takeshi, Sando, Norimasa, Yatabe, Yasushi, Mori, Naoyoshi
• Format: Journal Article
• Language: English
• Published: United States 01.04.2012
• Subjects: Aged; Biomarkers, Tumor - metabolism; Cell Transformation, Neoplastic; Combined Modality Therapy; Composite Lymphoma - metabolism; Composite Lymphoma - pathology; Composite Lymphoma - therapy; Fatal Outcome; Gastric Mucosa - pathology; Hodgkin Disease - metabolism; Hodgkin Disease - pathology; Hodgkin Disease - therapy; Humans; Lymphoma, B-Cell, Marginal Zone - metabolism; Lymphoma, B-Cell, Marginal Zone - pathology; Lymphoma, B-Cell, Marginal Zone - therapy; Male; Neoplasm Invasiveness; Neoplasms, Second Primary; Reed-Sternberg Cells - pathology; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology
• ISSN: 1940-2465
• DOI: 10.1177/1066896911417242

This report describes a 60-year-old man with concurrent gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) and classical Hodgkin lymphoma (CHL). Atypical, medium-sized, lymphoid cells proliferated in the mucosa to muscular layer of the stomach showing a lymphoepithelial lesion; admixed with Hodgkin/Reed-Sternberg (HRS) cells and an inflammatory cell background. MALT lymphoma cells expressed CD20, CD79a, PAX5, and BOB.1, and HRS cells expressed CD30, CD15, Epstein-Barr virus-encoded RNA, and EBV-latent membrane protein 1. Only CHL invaded into the regional lymph nodes. Two possibilities of transformation of MALT lymphoma into CHL and de novo CHL within MALT lymphoma are discussed.