Globularia arabica Methanolic Leaf Extract Has Higher Efficacy on Burn Wound Healing in Diabetic Rats Compared to Malva slyvestries Methanolic Leaf Extract

• Published in: Journal of burn care & research Vol. 44; no. 3; p. 563
• Main Authors: Alsarayreh, Ahmad Z, Khleifat, Khaled M, Al-Dalain, Sa'ed M, Al-Saraireh, Yousef M, Al Qaisi, Yaseen T, Alfarrayeh, Ibrahim I, Al-Qaraleh, Samer Y
• Format: Journal Article
• Language: English
• Published: England 02.05.2023
• Subjects: Animals; Burns - drug therapy; Burns - pathology; Diabetes Mellitus, Experimental; Malva; Methanol - pharmacology; Ointments; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plantaginaceae; Rats; Rats, Wistar; Wound Healing
• ISSN: 1559-0488
• DOI: 10.1093/jbcr/irac089

This study aimed to see how effective Globularia arabica and Malva slyvestries-based cream formulations were at healing scald burn wounds in rats. Depending on ointment, preparations of 1%, 5%, and 10% w/w were created. For comparison, an ointment base and a regular burn cream composed soframycine were utilized. Rats introduced a burn by solidifying equipment at 100°C on a 14-mm2 shaved dorsal region. A deep second-degree burn was created, and the percentage of wound contraction was measured over the next 15 days. The rats were euthanized on days 8 and 15, and histological slides were prepared using hematoxylin and eosin staining. Compared to the control group, there was a substantial increase in wound contraction and a significant decrease in the duration of epithelialization in the based ointment-treated groups. However, as paralleled to Globularia arabica, significant (P < .05) results were observed with 10% Globularia arabica cream, whereas Malva slyverstries indicate minimal healing. Soframycine causes a substantial increase in wound contraction (P < .05). Soframycine cream with 10% Globularia arabica therapy resulted in practically complete re-epithelialization and re-structuring of wound tissue on histological examination, whereas Malva slyversries treatment resulted in low epithelization during treatment days. The findings suggest that Globularia arabica-based cream has the wound-healing capability.