Light-triggered chemical amplification to accelerate degradation and release from polymeric particles

We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer bac...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 51; no. 95; pp. 16980 - 16983
Main Authors Olejniczak, Jason, Huu, Viet Anh Nguyen, Lux, Jacques, Grossman, Madeleine, He, Sha, Almutairi, Adah
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 11.12.2015
Subjects
Animals
Chemistry
Chemistry, Multidisciplinary
Drug Delivery Systems
Esters - chemistry
Esters - radiation effects
Fluoresceins - chemistry
Fluorescent Dyes - chemistry
Hydrogen-Ion Concentration
Hydrolysis
Mice
Nanoparticles - chemistry
Nanoparticles - radiation effects
Nylons - chemistry
Nylons - radiation effects
Oxazines - chemistry
Photolysis
Physical Sciences
RAW 264.7 Cells
Science & Technology
RESPONSES
SELF-IMMOLATIVE POLYMERS
DRUG-DELIVERY
KINETICS
HYDROLYSIS
PH
BIOMEDICAL APPLICATIONS
COPOLYMERS
DELIVERY VEHICLE
SOLID-STATE
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Summary:We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer backbone to accelerate ketal hydrolysis even at neutral pH.
Bibliography:NIH RePORTER
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc06143a