A metagenome-wide association study of gut microbiome in patients with AMD, ASD, RA, T2D & VKH diseases

• Published in: Computational biology and chemistry Vol. 110; p. 108076
• Main Authors: Tyagi, Shivani, Katara, Pramod
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2024
• Subjects: Gram-negative bacteria; Infectious diseases; Microbes; Microbial diversity, microbiome shift, De novo assembly; Pathogens; Pathogens; GI; SRA; T2D; RA; PCA; AUC; Microbial diversity, microbiome shift, De novo assembly; ASD; VKH; Infectious diseases; AMD; NCBI; Gram-negative bacteria; Microbes
• ISSN: 1476-9271; 1476-928X
• DOI: 10.1016/j.compbiolchem.2024.108076

Clinical studies have already illustrated the associations between gut microbes and diseases, yet fundamental questions remain unclear that how we can universalize this knowledge. Considering the important role of human gut microbial composition in maintaining overall health, it is important to understand the microbial diversity and altered disease conditions of the human gut. Metagenomics provides a way to analyze and understand the microbes and their role in a community manner. It provides qualitative as well as quantitative measurements, in terms of relative abundance. Various studies are already going on to find out the association between microbes and diseases; still, the mined knowledge is limited. Considering the current scenario, using the targeted metagenomics approach, we analyzed the gut microbiome of 99 samples from healthy and diseased individuals. Our metagenomic analysis mainly targeted five diseased microbiomes (i.e., Age-related macular degeneration, Autism spectrum disorder, Rheumatoid arthritis, Type 2 diabetes and Vogt-Koyanagi harada), with compare to healthy microbiome, and reported disease-associated microbiome shift in different conditions. [Display omitted] •Metagenomics provides a way to analyze and understand the microbes and their role in a community manner.•Disease-specific gut microbiome study may help to understand disease-specific microbial diversity and microbial shifting.•Five diseased microbiomes (i.e., AMD, ASD, RA, T2D, and VKH) have been studied for disease-specific microbiome shift.•Study reports disease-specific microbes that may help to cope with the disease and provide scope for microbe-based diagnosis.