Phenolic Compounds as Potent Free Radical Scavenging and Enzyme Inhibitory Components From the Leaves of Guiera senegalensis
Guiera senegalensis J.F. Gmel. (Combretaceae) is commonly used as a traditional medicine in Africa. In our previous study, the hydro-alcoholic extracts of the leaves of G. senegalensis showed potent free radical scavenging and enzyme inhibitory activities. Detailed chemical analysis of the 70% ethan...
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Published in | Natural product communications Vol. 14; no. 6 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Los Angeles, CA
SAGE Publications
01.06.2019
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Subjects | |
Online Access | Get full text |
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Summary: | Guiera senegalensis J.F. Gmel. (Combretaceae) is commonly used as a traditional medicine in Africa. In our previous study, the hydro-alcoholic extracts of the leaves of G. senegalensis showed potent free radical scavenging and enzyme inhibitory activities. Detailed chemical analysis of the 70% ethanol extract afforded 8 phenolic compounds including myricetin (1), myricitrin (2), quercetin (3), (-)-gallocatechin (4), 1,3,4,5-tetra-O-galloylquinic acid (5), gallic acid (6), methyl gallate (7), and ethyl gallate (8). Structures of these compounds were elucidated on the basis of NMR spectroscopic data. Among these compounds, 1,3,4,5-tetra-O-galloylquinic acid (5) (IC50= 7.21 ±0.21 µM), quercetin (3) (IC50 = 7.71 ± 0.17 µM), and myricitrin (2) (0.25 ± 0.03 µM) showed the most potent free radical scavenging, α-glucosidase inhibitory and pancreatic lipase inhibitory activities, respectively. |
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ISSN: | 1934-578X 1555-9475 |
DOI: | 10.1177/1934578X19857364 |