Effect of a high fat diet on plasma lipids, lipoprotein lipase, lecithin: cholesterol acyltransferase, and insulin function in adult rabbits

• Published in: The Journal of nutritional biochemistry Vol. 2; no. 11; pp. 616 - 622
• Main Authors: Mlekusch, W., Taupe, A.M., Vrecko, K., Schmid, P., Aloia, R.C.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.11.1991
• Subjects: ACILTRANSFERASA; ACYLTRANSFERASE; COMPOSICION DE LA CANAL; COMPOSITION DE LA CARCASSE; CONEJO (ORYCTOLAGUS); CORPS GRAS; diet; DIETA; fat; GRASAS; insulin; INSULINA; INSULINE; LAPIN; LCAT; LIPIDE; LIPIDOS; lipoprotein; LIPOPROTEINA LIPASA; LIPOPROTEINE LIPASE; PLASMA SANGUIN; PLASMA SANGUINEO; REGIME ALIMENTAIRE; fat; LCAT; diet; insulin; lipoprotein; acyltransferase
• ISSN: 0955-2863; 1873-4847
• DOI: 10.1016/0955-2863(91)90027-3

The influence of a high fat diet (19% wt./wt.) vs. a standard, chow diet (2% fat) on plasma lipids, lipoprotein lipase (LPL), lecithin:cholesterol acyltransferase (LCAT), glucose, and glucose tolerance, was investigated. Both diets had a similar fatty acid pattern and a polyunsaturated:saturated (P:S) fatty acid ratio of 2.7. The high fat diet elevated plasma triglycerides, phospholipids, and cholesterol concentrations and changed the percent distribution of cholesterol and phospholipids among the lipoprotein fractions. Additionally, LCAT and plasma glucose increased, while lipoprotein lipase and its products, free fatty acids and glycerol, were not altered. Glucose tolerance was significantly inhibited in animals on the high fat diet, which also exhibited a diminished insulin secretion. As such, the high fat diet seemed to evoke a diabetogenic situation. The return to the standard chow diet appeared to normalize, to a great extent, the alterations evoked by the high fat diet.