The C677T Mutation of the Methylenetetrahydrofolate Reductase Gene Is Not Associated with the Risk of Coronary Artery Disease or Venous Thrombosis among Chinese in Taiwan

• Published in: Human heredity Vol. 51; no. 1/2; pp. 41 - 45
• Main Authors: Hsu, Lung-An, Ko, Yu-Lin, Wang, Shu-Mei, Chang, Chi-Jen, Hsu, Tsu-Shiu, Chiang, Cheng-Wen, Lee, Ying-Shiung
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 2001
• Subjects: Alleles; Asian Continental Ancestry Group - genetics; Case-Control Studies; China - ethnology; Coronary Disease - ethnology; Coronary Disease - genetics; Female; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Original Paper; Oxidoreductases Acting on CH-NH Group Donors - genetics; Point Mutation; Polymorphism, Single Nucleotide; Risk Factors; Taiwan - epidemiology; Venous Thrombosis - ethnology; Venous Thrombosis - genetics; China; Taiwan; Venous thrombosis; Methylenetetrahydrofolate reductase; Mutation; Coronary disease
• ISSN: 0001-5652; 1423-0062
• DOI: 10.1159/000022958

Objectives: We sought to investigate the association between the methylenetetrahydrofolate reductase (MTHFR) gene C677T mutation and the risk of coronary artery disease (CAD), myocardial infarction (MI) and venous thrombosis (VT) in a Chinese population in Taiwan. Methods: The subjects included 218 CAD patients, 107 VT patients, and their age- and sex-matched controls. DNA was extracted from the blood and genotypes were determined by polymerase chain reaction, restriction mapping with HinfI and gel electrophoresis. Results: The distribution of MTHFR genotypes was similar in the CAD cases and controls; the genotype TT was present in 6.0% of CAD patients, as compared to 6.9% of CAD control subjects (p = 0.165; odds ratio = 0.86; 95% confidence interval = 0.40–1.85). The frequency of the T allele was also similar in CAD cases and controls (25.5% vs. 24.8%; p = 0.788). There was no significant association between TT homozygosity and the risk of MI. The genotype distributions and the frequency of the T allele were also similar in VT cases and controls. Conclusions: Our data suggest that there is no association between the C677T mutation of the human MTHFR gene and the risk of CAD or VT among Chinese in Taiwan.