Efficient construction of a quinoline framework from alcohols, nitroarenes, and alkenes promoted by a trimetallic catalyst system

A Pd/Fe/In-trimetallic catalyst system promotes the three-component coupling reaction of primary alcohols, nitroarenes, and terminal alkenes to construct quinoline frameworks in a single operation. These consecutive coupling reactions proceed via an oxidative Povarov reaction of alkenes and aldimine...

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Published inTetrahedron chem Vol. 12; p. 100108
Main Authors Horikawa, Rikiya, Onodera, Gen, Fukuda, Tsutomu, Kimura, Masanari
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.12.2024
Elsevier
Subjects
Hydrogen transfer
Indium
Iron
Palladium
Povarov reaction
Quinoline
Quinoline
Hydrogen transfer
Palladium
Iron
Povarov reaction
Indium
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Summary:A Pd/Fe/In-trimetallic catalyst system promotes the three-component coupling reaction of primary alcohols, nitroarenes, and terminal alkenes to construct quinoline frameworks in a single operation. These consecutive coupling reactions proceed via an oxidative Povarov reaction of alkenes and aldimines derived from primary alcohols and nitroarenes by a redox hydrogen transfer system. This reaction may contribute to the efficient development of pharmaceuticals and medicinal products. [Display omitted]
ISSN:2666-951X
2666-951X
DOI:10.1016/j.tchem.2024.100108