Effect of synthetic phospholipids on platelet aggregation and serotonin release
1‐O‐Hexadecyl‐2‐O‐acetyl‐sn‐glycerol‐3‐phosphocholine (platelet‐activating factor, PAF) is known to stimulate platelet aggregation and serotonin release in concentrations ranging from 10−10–10−5 M. Since a variety of synthetic PAF analogues are potent antineoplastic agents in vitro and in vivo, it w...
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Published in | Lipids Vol. 22; no. 11; pp. 868 - 870 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer‐Verlag
01.11.1987
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Subjects | |
Online Access | Get full text |
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Summary: | 1‐O‐Hexadecyl‐2‐O‐acetyl‐sn‐glycerol‐3‐phosphocholine (platelet‐activating factor, PAF) is known to stimulate platelet aggregation and serotonin release in concentrations ranging from 10−10–10−5 M. Since a variety of synthetic PAF analogues are potent antineoplastic agents in vitro and in vivo, it was the aim of this study to examine the PAF‐like activity of 15 analogues, including 1‐O‐actadecyl‐2‐O‐methyl‐rac‐glycero‐3‐phosphocholine (ET‐18‐OCH3) and a thioether analogue. In platelet‐rich plasma from human blood, platelet aggregation and serotonin release were studied to compare the effects on PAF and the analogues. Platelet function was controlled by testing their response to adenosine diphosphate, arachidonic acid, collagen and epinephrine. Our results show that only PAF was able to induce platelet aggregation and serotonin release in concentrations from 10−9 to 10−5 M, whereas all the tested analogues up to a concentration of 10−3 M failed to induce these effects. |
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Bibliography: | Presented at the symposium on “Ether Lipids in Oncology,” Göttingen, Federal Republic of Germany, December 1986. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0024-4201 1558-9307 |
DOI: | 10.1007/BF02535546 |