Glycodihydrofusidate: Biliary excretion and its effect on biliary secretion of the rat

Glycodihydrofusidate, which has the same detergent properties as bile salts, is excreted almost exclusively by the bile duct after intravenous injection in the rat. As with bile salts, it leads to a significant (P≤0.05) increase in excretion of lecithins and cholesterol (0.15 μmol lecithin and 0.026...

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Published inLipids Vol. 11; no. 5; pp. 408 - 411
Main Authors Montet, J. C., Montet, A. M., Gerolami, A., Amic, J., Hauton, J. C.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer‐Verlag 01.05.1976
Subjects
Animals
Bile - metabolism
Bile Acids and Salts - metabolism
Fusidic Acid - metabolism
Glycolipids - metabolism
Liver - metabolism
Male
Rats
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Summary:Glycodihydrofusidate, which has the same detergent properties as bile salts, is excreted almost exclusively by the bile duct after intravenous injection in the rat. As with bile salts, it leads to a significant (P≤0.05) increase in excretion of lecithins and cholesterol (0.15 μmol lecithin and 0.026 μmol cholesterol per 1 μmol of glycodihydrofusidate excreted). In addition, this drug simultaneously inhibits excretion of both endogenous bile salts and bile pigments.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0024-4201
1558-9307
DOI:10.1007/BF02532848