Genetic polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7 and the risk for benign Warthin's tumors of the parotid gland

Background Warthin's tumors of the parotid gland are associated with smoking, whereas pleomorphic adenomas are not. Genetic polymorphisms in biotransformation enzymes, involved in detoxification of toxins and carcinogens in cigarette smoke, might modify the corresponding enzyme activity and inf...

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Published inHead & neck Vol. 38; no. S1; pp. E717 - E723
Main Authors Lacko, Martin, Voogd, Adri C., van de Goor, Rens C.E., Roelofs, Hennie M.J., te Morsche, Rene H.M., Bouvy, Nicole D., Peters, Wilbert H.M., Manni, Johannes J.
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.04.2016
Subjects
Adenolymphoma - genetics
Adolescent
Adult
Aged
Aged, 80 and over
biotransformation enzyme
Case-Control Studies
Female
genetic predisposition
Genotype
Glucuronosyltransferase - genetics
Humans
Male
Middle Aged
Parotid Gland - pathology
parotid neoplasm
Parotid Neoplasms - genetics
Polymorphism, Genetic
Risk Factors
Smoking
UDP-glucuronosyltransferase
Warthin's tumor
Young Adult
genetic predisposition
biotransformation enzyme
parotid neoplasm
UDP-glucuronosyltransferase
Warthin's tumor
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Summary:Background Warthin's tumors of the parotid gland are associated with smoking, whereas pleomorphic adenomas are not. Genetic polymorphisms in biotransformation enzymes, involved in detoxification of toxins and carcinogens in cigarette smoke, might modify the corresponding enzyme activity and influence detoxifying capacity. We hypothesize that these genetic polymorphisms may influence the individual risk for Warthin's tumor, but not for pleomorphic adenomas. Methods Blood from 146 patients with benign parotid gland tumors and 437 controls were investigated for polymorphisms in several biotransformation enzymes. Based on these polymorphisms, patients and controls were divided according to predicted enzyme activity (low, intermediate, and high). Results Prevalence of predicted intermediate and high activity UGT1A7 and UGT1A6 genotypes was significantly higher in the patients with Warthin's tumors, but not in patients with pleomorphic adenomas, compared with healthy controls. Conclusion Predicted intermediate and high activity UGT1A7 and UGT1A6 genotypes are associated with an increased risk for Warthin's tumor. © 2015 Wiley Periodicals, Inc. Head Neck 38: E717–E723, 2016
Bibliography:ark:/67375/WNG-MX6CZHWB-K
istex:F1FB1893E9FA0F7D468AC58DF52127A5B675532F
ArticleID:HED24077
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.24077