Importance of Vascular Changes in Selective Neurodegeneration with Thiamine Deficiency

These results demonstrate that early alterations in the BBB may underlie selective vulnerability in this model of chronic reduced oxidative metabolism. Changes in the BBB (IgG extravasation) precede alterations in APP processing and cell death. Since thiamine-dependent enzymes are also reduced in th...

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Bibliographic Details
Published inAnnals of the New York Academy of Sciences Vol. 826; no. 1; pp. 516 - 519
Main Authors GIBSON, G. E., CALINGASAN, N. Y., BAKER, H., GANDY, S., SHEU, K.-F. R.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.09.1997
Subjects
Amyloid beta-Protein Precursor - metabolism
Blood-Brain Barrier
Cerebrovascular Circulation
Humans
Nerve Degeneration - pathology
Pyrophosphatases - metabolism
Thiamine Deficiency - pathology
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Summary:These results demonstrate that early alterations in the BBB may underlie selective vulnerability in this model of chronic reduced oxidative metabolism. Changes in the BBB (IgG extravasation) precede alterations in APP processing and cell death. Since thiamine-dependent enzymes are also reduced in the brain in Alzheimer's disease, similar processes may be important in the pathophysiology of the disease.
Bibliography:ark:/67375/WNG-CTQLXL5T-S
ArticleID:NYAS516
istex:3F0083D429C9B2BB12DCD6E3B7AF152FB8CD8EFC
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1997.tb48517.x