Modulation of chemical carcinogenesis in rats by alkyl lysophospholipids

• Published in: Lipids Vol. 22; no. 11; pp. 935 - 942
• Main Authors: Berger, Martin R., Schmähl, Dietrich
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer‐Verlag 01.11.1987
• Subjects: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Antineoplastic Agents - therapeutic use; Dose-Response Relationship, Drug; Female; Leukemia, Experimental - chemically induced; Leukemia, Experimental - drug therapy; Lysophospholipids - therapeutic use; Male; Mammary Neoplasms, Experimental - chemically induced; Mammary Neoplasms, Experimental - drug therapy; Methylnitrosourea; Neoplasms, Experimental - chemically induced; Neoplasms, Experimental - drug therapy; Organophosphates - therapeutic use; Organophosphorus Compounds - therapeutic use; Phospholipid Ethers - therapeutic use; Rats; Rats, Inbred Strains
• ISSN: 0024-4201; 1558-9307
• DOI: 10.1007/BF02535559

The influence of 1‐O‐octadecyl‐2‐O‐methyl‐rac‐glycero‐3‐phosphocholine (ET‐18‐OCH3) and 1‐hexadecylmercapto‐2‐methoxymethyl‐rac‐propyl‐3‐phosphocholine (TLP, BM41.440) on methylnitrosourea (MNU)‐induced rat mammary carcinomas and of ET‐18‐OCH3 on 7,12‐dimethylbenzanthracene (DMBA)‐induced leukemias was investigated. Both agents effectively delayed MNU‐induced mammary tumor formation at high, cytotoxic dosages but TLP had no influence at low “immunomodulatory” doses. ET‐18‐OCH3 also significantly protected against leukemia development in DMBA‐treated Long‐Evans rats.