Inherent Abnormalities in Oxidative Metabolism in Alzheimer's Disease: Interaction with Vascular Abnormalities

Extensive studies over the last 20 years have documented the existence of inherent abnormalities in oxidative/energy metabolism in Alzheimer's disease (AD). These abnormalities can be linked to characteristics of AD by plausible pathophysiological mechanisms for which there is abundant, robust...

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Bibliographic Details
Published inAnnals of the New York Academy of Sciences Vol. 826; no. 1; pp. 382 - 385
Main Authors BLASS, JOHN P., SHEU, KWAN-FU R., PIACENTINI, SILVIA, SORBI, SANDRO
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.09.1997
Subjects
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Brain - metabolism
Cerebrovascular Circulation
Energy Metabolism
Glucose - metabolism
Humans
In Vitro Techniques
Oxygen - metabolism
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Summary:Extensive studies over the last 20 years have documented the existence of inherent abnormalities in oxidative/energy metabolism in Alzheimer's disease (AD). These abnormalities can be linked to characteristics of AD by plausible pathophysiological mechanisms for which there is abundant, robust evidence. The inherent abnormalities in cerebral metabolism of oxygen and glucose can reasonably be expected to interact synergistically with vascular compromise of cerebral oxygen and glucose metabolism in causing brain damage in AD.
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ark:/67375/WNG-NC5G4JKN-0
ArticleID:NYAS382
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1997.tb48488.x