HHV8-positive multicentric Castleman’s disease and thrombotic thrombocytopenic purpura among HIV-positive patients

• Published in: European journal of case reports in internal medicine Vol. 11; no. 3; p. 004361
• Main Authors: Pasquer, Roxane, Dieudonné, Yannick, Decours, Pauline, Hinschberger, Olivier, Nicolae, Alina, Martinot, Martin
• Format: Journal Article
• Language: English
• Published: Italy SMC Media Srl 2024; SMC MEDIA SRL
• Subjects: auto-immune hypoglycemia; castleman’s disease; hhv8; hiv; thrombotic thrombocytopenic purpura; Castleman’s disease; thrombotic thrombocytopenic purpura; HHV8; HIV; autoimmune hypoglycaemia
• ISSN: 2284-2594; 2284-2594
• DOI: 10.12890/2024_004361

Castleman’s disease (CD) and thrombotic thrombocytopenic purpura (TTP) are rare diseases that can affect the general population, especially those with HIV. Owing to their rarity, the association between CD and TTP remains insufficiently understood. In this study, we present a case of a 53-year-old patient with controlled HIV infection who presented with fever, lymphadenopathy, severe anaemia, and thrombocytopenia. After a series of tests, the diagnosis was concurrent human herpesvirus 8 (HHV8)-related multicentric CD (MCD) and TTP. Only four male patients were previously reported having this association, with HHV8 present in four and HIV in three patients, suggesting that coinfection with HHV8 and HIV is a pivotal factor in MCD with TTP occurrence.