The signaling pathway in modulating bone metabolism after dental implant in diabetes

Diabetes Mellitus is a systematic disease with complications in multi-organs, including decreased implant osseointegration and a high failure rate of dental transplants. Accumulating evidence indicates that the signaling pathway directly impacts the process of bone metabolism and inflammatory respon...

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Published inBiocell Vol. 45; no. 6; pp. 1509 - 1519
Main Authors HAN, XIAOMEI, ZHANG, SHUYING, WANG, YIFU, QI, CHANGE, GUO, PENGNYU, XU, YALI, LYU, GUANGHUI
Format Journal Article
LanguageEnglish
Published Mendoza Tech Science Press 2021
Subjects
Adiponectin
Bone implants
Bone turnover
Dental prosthetics
Diabetes
Diabetes mellitus
Inflammation
Metabolism
Osseointegration
Peroxisome proliferator-activated receptors
Signal transduction
Transplantation
Transplants & implants
Wnt protein
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Summary:Diabetes Mellitus is a systematic disease with complications in multi-organs, including decreased implant osseointegration and a high failure rate of dental transplants. Accumulating evidence indicates that the signaling pathway directly impacts the process of bone metabolism and inflammatory response implicated with dental implants in diabetic patients. This review summarizes the recent advance in signaling pathways regulate osseointegration and inflammatory response in dental transplantation, aiming to identify the potential therapeutic target to reduce the dental transplant failure in diabetes patients, with emphasis on the surface characteristics of the implant, inflammatory signaling, AMPK, PPARγ, WNT, ROS, and adiponectin signaling.
ISSN:1667-5746
0327-9545
DOI:10.32604/biocell.2021.09506