Vitamin D Receptor Gene BSMI, FOKI, APAI, and TAQI Polymorphisms and the Risk of Atopic Dermatitis

• Published in: Journal of investigational allergology & clinical immunology Vol. 26; no. 2; pp. 106 - 110
• Main Authors: Kilic, S, Silan, F, Hiz, M M, Isik, S, Ogretmen, Z, Ozdemir, O
• Format: Journal Article
• Language: English
• Published: Spain 01.01.2016
• Subjects: Adolescent; Adult; Alleles; Case-Control Studies; Cross-Sectional Studies; Dermatitis, Atopic - diagnosis; Dermatitis, Atopic - genetics; Dermatitis, Atopic - pathology; DNA Restriction Enzymes - chemistry; Gene Expression; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Heterozygote; Homozygote; Humans; Male; Middle Aged; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Receptors, Calcitriol - genetics; Risk Factors; BsmI; TaqI; rs2228570; rs731236; FokI; ApaI; rs1544410; rs7975232
• ISSN: 1018-9068
• DOI: 10.18176/jiaci.0020

The association between vitamin D receptor (VDR) gene polymorphisms and the risk of skin diseases has been widely studied, yet there is only one study on atopic dermatitis. In this study, we aimed to investigate the association between 4 VDR polymorphisms and atopic dermatitis. This cross-sectional case control study was performed between March 2013 and April 2014 at the University Hospital in Çanakkale, Turkey. Peripheral blood samples were collected in EDTA tubes. DNA extraction was performed using the spin column procedure. The VDR polymorphisms FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236) were determined by polymerase chain reaction-restriction fragment length polymorphism analysis in 42 atopic dermatitis patients and 96 healthy individuals from a Turkish population. The VDR rs1544410 polymorphism increased the risk of atopic dermatitis in our Turkish population [OR, 12.2; 95%CI, 0.44-336; P=.05]. The FoqI, TaqI, and ApaI polymorphisms were not significantly associated with atopic dermatitis susceptibility. The VDR Fok1, TaqI, and ApaI gene polymorphisms were not associated with the risk of atopic dermatitis in the Turkish population but the BsmI polymorphism was found to increase risk.