Radiopharmaceuticals for scintigraphic imaging of infection and inflammation

Scintigraphic imaging of infection and inflammation is a powerful diagnostic tool in the management of patients with infectious or inflammatory diseases. Most infectious and inflammatory foci can be visualized accurately with radiolabeled autologous leukocytes. However, preparation of this radiophar...

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Published inInflammation research Vol. 50; no. 2; pp. 55 - 64
Main Authors Boerman, O C, Dams, E T, Oyen, W J, Corstens, F H, Storm, G
Format Journal Article
LanguageEnglish
Published Switzerland 01.02.2001
Subjects
Antibodies
Citric Acid
Gallium Radioisotopes
Granulocytes - immunology
Humans
Immunoglobulin G
Infection - diagnostic imaging
Inflammation - diagnostic imaging
Interleukins
Isotope Labeling
Leukocytes
Liposomes
Radionuclide Imaging
Radiopharmaceuticals
Technetium
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Summary:Scintigraphic imaging of infection and inflammation is a powerful diagnostic tool in the management of patients with infectious or inflammatory diseases. Most infectious and inflammatory foci can be visualized accurately with radiolabeled autologous leukocytes. However, preparation of this radiopharmaceutical is laborious and requires the handling of potentially contaminated blood. Nowadays, a few radiopharmaceuticals are available that could replace radiolabeled leukocytes, such as: 67Ga-citrate, 99mTc-IgG and 99mTc-labeled antigranulocyte antibody preparations. Furthermore, various agents labeled with 99mTc are currently developed for this application: chemotactic peptides, cytokines and liposomes. Here, the characteristics and the diagnostic potential of established and experimental radiopharmaceuticals for infection and inflammation imaging are reviewed.
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ISSN:1023-3830
1420-908X
DOI:10.1007/s000110050725